HCID 58650613, Verbindung → HCID 58650608, Verbindung

Temperatur

130 °C

{[(5S,2R)-5-methyl-4-benzylmorpholin-2-yl]methyl}dimethylamine (1 equivalent), was dissolved in EtOH and the solution was transferred to a stainless steel high pressure vessel equipped with a pressure gauge. 10% Pd/C was added (10 wt. %), and the vessel charged with H2. The reaction mixture was stirred at 130° C. and 200 psi of H2 overnight. The reaction mixture was cooled to room temperature, filtered over a pad of Celite, and then evaporated. The desired amine was obtained in quantitative yield as a pale yellow oil. GC/MS: 128 (10%, M+−2×CH3), 58 (100%, NHCH2CHO), Rt=8.16 minutes.

1. customthe solution was transferred to a stainless steel high pressure vessel
2. customequipped with a pressure gauge
3. additionthe vessel charged with H2
4. custom200 psi of H2 overnight
5. temperatureThe reaction mixture was cooled to room temperature
6. filtrationfiltered over a pad of Celite
7. customevaporated

ORD-Eintrag

ord-f2b29d8b896047daaa91d1e56e421986

Quelldatensatz

uspto-grants-2010_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07642278B2