Hydrazine hydrate (1:1) → HCID 59128632, Verbindung

HRID 1991017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1991017
[CH2:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:7](OC)=[O:8])[CH:2]=[CH2:3].O.[NH2:16][NH2:17]>C(O)C>[CH2:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:7]([NH:16][NH2:17])=[O:8])[CH:2]=[CH2:3]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 591286443-Allyl-4-methyl-benzoic acid methyl ester

Produkt 1

HCID 59128632HCID 59128632, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of methyl 3-allyl-4-methylbenzoate (2.84 g, 15 mmol) and hydrazine hydrate (2.1 mL, 37.5 mmol) in ethanol (5 mL) was heated to 100° C. for 6 hours. After cooling, the mixture was partitioned between ethyl acetate and water, and the combined organic layers were washed with brine, dried (MgSO4), filtered, and concentrated under reduced pressure to give 3-allyl-4-methyl-benzoic acid hydrazide as a white solid. (Yield 2.80 g, 98.1%).

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe mixture was partitioned between ethyl acetate and water
  3. washthe combined organic layers were washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7d235f74240e4359a99e3522c0402d53
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07645764B2

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