Hydrochloric Acid → 2-(3-Bromophenyl)propan-2-amine hydrochloride

HRID 1991531Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1991531
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH2:11])([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[ClH:12]>CCOCC.C(O)C.C(OCC)(=O)C>[ClH:12].[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH2:11])([CH3:9])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 130256661-(3-Bromophenyl)-1-methylethylamine

Produkt 1

HCID 532565432-(3-Bromophenyl)propan-2-amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To 2-(3-bromophenyl)-2-propylamine 29 in ether is added ethereal HCl. Solvent removal affords a tan solid, which is dissolved in a small volume of ethanol and diluted with ethyl acetate. The tan crystals which form are filtered to afford 2-(3-bromophenyl)-2-propylamine hydrochloride: 1H NMR (CDCl3+CD3OD drop) δ 7.65 (n m, 1H), 7.51 (app t, 2H), 7.32 (m, 1H), 1.77 (s, 6H); MS (CI) m/z 214.0 (MH+)

Aufarbeitung

  1. customSolvent removal
  2. customaffords a tan solid, which
  3. filtrationThe tan crystals which form are filtered

Quellen und Nachweise

ORD-Eintrag
ord-6e878682fe944d968eef2c68719566a5
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07645780B2

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