Water → 2,4-Dichloro-5-methylpyridine

HRID 1992648Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1992648
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH2:9]Cl)=[CH:4][N:3]=1.C(N(CC)CC)C.O>C(O)C.[Ni].CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH3:9])=[CH:4][N:3]=1

Komponenten

7

Edukt 3

HCID 962WaterHCID 8471TriethylamineHCID 27627282,4-Dichloro-5-(chloromethyl)pyridine

Produkt 1

HCID 126437182,4-Dichloro-5-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2,4-Dichloro-5-chloromethyl-pyridine (1.43 g, 7.28 mmol) is dissolved in ethanol (14 ml). After addition of triethyl amine (737 mg, 7.28 mmol), Raney nickel (143 mg) is added. The reaction vessel is connected to a balloon filled with H2. After 3 hours of very vigorous magnetically stirring at RT, NMR analysis of a reaction aliquot indicated complete conversion of the starting material. The reaction mixture is diluted with EtOAc and poured into water.

Aufarbeitung

  1. additionis added
  2. additionfilled with H2
  3. customNMR analysis of a reaction aliquot indicated complete conversion of the starting material

Quellen und Nachweise

ORD-Eintrag
ord-79a391b269bb465b85cdd312f2bedf29
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07648989B2

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