Pyridinium chloride → 2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol

HRID 1993368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1993368
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[N:12][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[N:11]=[N:12][C:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:14][CH:15]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

Komponenten

3

Edukt 2

HCID 10176127Pyridinium chlorideHCID 574454003-(3-Fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine

Produkt 1

HCID 1360707052-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

A mixture of 3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine (Step 1, 0.60 g, 2.0 mmol) and pyridine hydrochloride (3 g) was heated in an oil bath at 170° C. for 8 h. The sublimed pyridine hydrochloride on the top of the reaction flask was removed, and the residue (0.65 g) was used in the next step without further purification. MS (ESI pos. ion) m/z: 283.1 (M+H). Calc'd Exact Mass for C16H11FN2O2: 282.27.

Aufarbeitung

  1. customThe sublimed pyridine hydrochloride on the top of the reaction flask was removed
  2. customthe residue (0.65 g) was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-0e6be287f8ed412a89bbf6605cbdc0f7
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07652009B2

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