Water → 5-Trifluoromethyl-indan-2-yl-methanol

The above 5-trifluoromethyl-indan-2-carboxylic acid (1.03 g, 4.47 mmol) was dissolved in THF (25 mL) and cooled to 0° C. To this solution was added a solution of borane in THF (1M, 6.5 mL). The mixture was warmed to room temperature and stirred for 1 hr. The mixture was treated with water (5 mL) and solvents were evaporated. The residue was extracted with ether and hydrochloric acid (1M). The organic phase was washed with brine and sodium bicarbonate solution. The ether solution was dried and solvents were evaporated to give oily material as 5-trifluoromethyl-indan-2-yl-methanol (0.98 g).

1. temperatureThe mixture was warmed to room temperature
2. customwere evaporated
3. extractionThe residue was extracted with ether and hydrochloric acid (1M)
4. washThe organic phase was washed with brine and sodium bicarbonate solution
5. dry with materialThe ether solution was dried
6. customsolvents were evaporated

ORD-Eintrag

ord-fdad3ff1ca1b4aeab707bd15f25a1d48

Quelldatensatz

uspto-grants-2010_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07652053B2