Methanol → 1-Fluoro-3-methoxy-2-nitrobenzene

HRID 1994440Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1994440
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[C:3]=1[N+:9]([O-:11])=[O:10].[OH-:12].[K+].O.[CH3:15]O>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:12][CH3:15])[C:3]=1[N+:9]([O-:11])=[O:10]

Komponenten

5

Edukt 4

HCID 887MethanolHCID 962WaterHCID 14797Potassium HydroxideHCID 879221,3-Difluoro-2-nitrobenzene

Produkt 1

HCID 27827761-Fluoro-3-methoxy-2-nitrobenzeneAusbeute 95 %

Versuchsvorschrift

To a solution of 2,6-difluoronitrobenzene (5 g, 32 mmol) in methanol (50 mL) was added potassium hydroxide (1.8 g, 32.5 mmol), and the mixture was heated to reflux for 3 hr. Water was added, and the mixture was extracted with dichloromethane. The organic layer was separated, dried, filtered, and evaporated to yield 5.1 g (95%) of 1-fluoro-3-methoxy-2-nitrobenzene, 1e. MS m/z (MH+) 172.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 3 hr
  3. extractionthe mixture was extracted with dichloromethane
  4. customThe organic layer was separated
  5. customdried
  6. filtrationfiltered
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-4b12df4a7eea49bd87126316c26eb897
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07652005B2

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