Water → 3-(3,5-Difluorophenyl)-1-propene
Reaktionsgleichung
[CH2:1](Br)[CH:2]=[CH2:3].[F:5][C:6]1[CH:7]=[C:8](Br)[CH:9]=[C:10]([F:12])[CH:11]=1.[Mg].O>O1CCCC1>[CH2:3]([C:8]1[CH:7]=[C:6]([F:5])[CH:11]=[C:10]([F:12])[CH:9]=1)[CH:2]=[CH2:1]Komponenten
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 20 °C
Versuchsvorschrift
A solution of allyl bromide (2.5 g) in dry tetrahydorfuran (10 ml) was added dropwise with stirring to 3,5-difluorobromobenzene (4.0 g) with magnesium (0.5 g) in dry tetrahydrofuran) in dry tetrahydrofuran (40 ml), whilst maintaining the temperature of the mixture at about 20° C. When the addition was complete the mixture was allowed to warm to the ambient temperature (ca. 25° C.) After a period of 18 hours the mixture was poured into water (100 ml) and the resultant mixture extracted with diethyl ether, the extract washed with water, dried over anhydrous magnesium sulphate and the ether removed by distillation at atmospheric pressure. The residual oil was purified by distillation at atmospheric pressure to yield allyl-3,5-difluorobenzene (b.p. 154-155°) as a colourless oil.
Aufarbeitung
- additionWhen the addition
- temperatureto warm to the ambient temperature (ca. 25° C.) After a period of 18 hours the mixture
- extractionthe resultant mixture extracted with diethyl ether
- washthe extract washed with water
- dry with materialdried over anhydrous magnesium sulphate
- customthe ether removed by distillation at atmospheric pressure
- distillationThe residual oil was purified by distillation at atmospheric pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-c171fe693bb8473fa17cf85cb264ebbb
- Quelldatensatz
- uspto-grants-1983_09
- Patentnummer
- US04405640
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