5-[(4-Chlorophenyl)methoxy]-2-nitropyridine → 5-[(4-Chlorophenyl)methoxy]pyridin-2-amine

HRID 1995821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1995821
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][C:8]2[CH:9]=[CH:10][C:11]([N+:14]([O-])=O)=[N:12][CH:13]=2)=[CH:4][CH:3]=1>O.CO>[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([O:7][CH2:6][C:5]2[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:13][N:12]=1

Komponenten

4

Edukt 1

HCID 204861295-[(4-Chlorophenyl)methoxy]-2-nitropyridine

Produkt 1

HCID 204861125-[(4-Chlorophenyl)methoxy]pyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

A mixture of 5-(4-chlorobenzyloxy)-2-nitropyridine (0.5 g), Na2S (0.25 g) and methanol (12 ml) is heated to reflux for about 3 hours. Then, a few drops of water is added and refluxing continued about 15 hours. After cooling, the reaction is diluted with methanol, filtered through celite and stripped. The concentrate is taken up in CHCl3, washed with water, dried and stripped giving 2-amino-5-(4-chlorobenzyloxy)pyridine.

Aufarbeitung

  1. temperatureis heated
  2. temperatureto reflux for about 3 hours
  3. temperaturerefluxing
  4. temperatureAfter cooling
  5. filtrationfiltered through celite
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a45c41810db74af795ff44402984949c
Quelldatensatz
uspto-grants-1983_09
Patentnummer
US04406690

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