Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate → Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

HRID 2017

Reaktionsgleichung

Reaktionsgleichung von HRID 2017
C([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:29])([O:26][CH2:27][CH3:28])[O:23][CH2:24][CH3:25])[C:13](=[O:30])[N:12]([CH3:31])[C:11]=2[N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:31][N:12]1[C:11]2[N:10]=[CH:9][NH:8][C:16]=2[C:15](=[O:17])[N:14]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:29])([O:23][CH2:24][CH3:25])[O:26][CH2:27][CH3:28])[C:13]1=[O:30]

Komponenten

4

Edukt 1

HCID 22446297Diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]phosphonate

Produkt 1

HCID 22446315Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

15.7 g (0.035 mol) of diethyl [4-(7-benzyl-3-methylxanthin-1-yl)butyl]-phosphonate were hydrogenated in 150 ml of ethanol over 1 g of palladium (10%) on active carbon at room temperature in the course of 8 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure and the residue was crystallized from diisopropyl ether.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customthe residue was crystallized from diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-ecb037eb61a74599a6353b1d72d5a468
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728686

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