Chloroiodomethane → Di-tert-butyl (chloromethyl) phosphate

HRID 20212

Reaktionsgleichung

Reaktionsgleichung von HRID 20212
[C:1]([O:5][P:6]([O-:13])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([N+](CCCC)(CCCC)CCCC)CCC.[Cl:31][CH2:32]I>>[P:6]([O:13][CH2:32][Cl:31])([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7]

Komponenten

3

Edukt 2

HCID 11644ChloroiodomethaneHCID 22339116Tetra-n-butylammonium di-tert-butylphosphate

Produkt 1

HCID 11701630Di-tert-butyl (chloromethyl) phosphate

Versuchsvorschrift

A mixture of tetrabutylammonium di-tert-butyl phosphate (57 g, 0.126 mol, Digital Specialty Chemicals) and chloroiodomethane (221 g, 1.26 mol) was stirred at room temperature for four hours before the volatiles were removed under vacuum. 500 ml of ethyl ether was added to the residue and insoluble solid was filtered away. Concentration of the filtrate in vacuo and removal of remaining volatiles using a vacuum pump provided di-tert-butyl chloromethyl phosphate as a light brown or yellow oil, which was utilized in the next step without further purification.

Aufarbeitung

  1. customwere removed under vacuum
  2. addition500 ml of ethyl ether was added to the residue and insoluble solid
  3. filtrationwas filtered away
  4. customConcentration of the filtrate in vacuo and removal of remaining volatiles

Quellen und Nachweise

ORD-Eintrag
ord-56a2fca1e2d24473a6fdd37fbe0d53ca
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745625B2

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