Iodoethane → Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

HRID 2023

Reaktionsgleichung

Reaktionsgleichung von HRID 2023
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[N:4]([CH2:12][CH2:13][CH2:14][CH2:15][P:16](=[O:23])([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19])[C:3]1=[O:24].[CH2:25](I)[CH3:26].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:25]([N:7]1[C:6]2[C:5](=[O:11])[N:4]([CH2:12][CH2:13][CH2:14][CH2:15][P:16](=[O:23])([O:17][CH2:18][CH3:19])[O:20][CH2:21][CH3:22])[C:3](=[O:24])[N:2]([CH3:1])[C:10]=2[N:9]=[CH:8]1)[CH3:26]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 22446315Diethyl [4-(3-methylxanthin-1-yl)butyl]phosphonate

Produkt 1

HCID 22446294Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. filtrationfiltered again
  4. customcrystallized from diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-056956b73b9f45e9955998f708e34b9b
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728686

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