Triethylamine → N-(4-chlorophenyl)-4-cyano-4-phenylpiperidine-1-carbothioamide

HRID 20277

Reaktionsgleichung

Reaktionsgleichung von HRID 20277
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[S:17])=[CH:11][CH:10]=1.Cl.[C:19]([C:21]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)#[N:20]>ClCCl>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([N:24]2[CH2:25][CH2:26][C:21]([C:19]#[N:20])([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:22][CH2:23]2)=[S:17])=[CH:11][CH:10]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 164804-Chlorophenyl isothiocyanateHCID 30849734-Phenylpiperidine-4-carbonitrile hydrochloride

Produkt 1

HCID 3875011N-(4-chlorophenyl)-4-cyano-4-phenylpiperidine-1-carbothioamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Triethylamine (1.4 mL, 10 mmol) was added to a suspension of 4-chlorophenyl isothiocyanate (1.69 g, 10 mmol) and 4-cyano-4-phenylpiperidine hydrochloride (2.22 g, 10 mmol) in dichloromethane (100 mL), and the reaction was then stirred at room temperature for 20 minutes. The mixture was washed with 2N hydrochloric acid, then brine, it was dried over MgSO4 and evaporated under reduced pressure to afford the title compound as a white solid, 3.62 g.

Aufarbeitung

  1. washThe mixture was washed with 2N hydrochloric acid
  2. dry with materialbrine, it was dried over MgSO4
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e59ae674d51d457999a3180b2ce91eb5
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745630B2

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