4-Chlorophenyl isothiocyanate → tert-Butyl 4-{[(4-chlorophenyl)amino]carbonothioyl}-1,4-diazepane-1-carboxylate

HRID 20278

Reaktionsgleichung

Reaktionsgleichung von HRID 20278
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[C:11]([N:18]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:21]2[CH2:22][CH2:23][CH2:24][N:18]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:19][CH2:20]2)=[S:10])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 164804-Chlorophenyl isothiocyanateHCID 2756058Tert-butyl 1,4-diazepane-1-carboxylate

Produkt 1

HCID 59347509tert-Butyl 4-{[(4-chlorophenyl)amino]carbonothioyl}-1,4-diazepane-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 4-chlorophenyl isothiocyanate (5.0 g, 29.95 mmol), and BOC-homopiperazine (6.0 g, 29.95 mmol) in ethanol (50 mL) was stirred at room temperature for 2 hours. The mixture was evaporated under reduced pressure, the residue was partitioned between ethyl acetate and water and the layers were separated. The organic phase was dried over MgSO4 and evaporated under reduced pressure to give the title compound as a white foam.

Aufarbeitung

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue was partitioned between ethyl acetate and water
  3. customthe layers were separated
  4. dry with materialThe organic phase was dried over MgSO4
  5. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-daa6eab60c9e4f4fa2b20aee2c27aaac
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745630B2

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