6-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester → HCID 67412646, Verbindung

HRID 2035547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2035547
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:19]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[C:20]2[CH:21]=[N:22][C:23]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[CH:24][CH:25]=2)=[CH:10][C:11]=1[NH:12]C(=O)C(F)(F)F)=[O:5])[CH3:2]>CO.C(=O)([O-])[O-].[K+].[K+].O>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:19]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=2)[C:20]2[CH:21]=[N:22][C:23]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)=[CH:24][CH:25]=2)=[CH:10][C:11]=1[NH2:12])=[O:5])[CH3:2]

Komponenten

5

Edukt 1

HCID 866579436-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester

Produkt 1

HCID 67412646HCID 67412646, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×HCID 11430Potassium CarbonateLösungsmittel

Versuchsvorschrift

51 mg of 6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester was dissolved in 5 mL of methanol, to which 3 mL of 2 mol/L potassium carbonate in water was added, and stirred at room temperature for 4 hours. To the reaction mixture water was added, extracted with ethyl acetate, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 42 mg (yield 100%) of the title compound as a light yellow solid.

Aufarbeitung

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. washthe extract was washed with saturated saline
  4. dry with materialdried on anhydrous sodium sulfate
  5. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-9ee59c8823ed4d239c60dcbdef661608
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575153B2

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