1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 2036069

Reaktionsgleichung

Reaktionsgleichung von HRID 2036069
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH2:18][CH2:17]1

Komponenten

5

Edukt 2

HCID 531671-MethylpiperazineHCID 949542-Fluoro-5-nitrobenzotrifluoride

Produkt 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at room temperature overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methylpiperazino)-5-nitrobenzotrifluoride.

Aufarbeitung

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-04933d5b4e924d9c87cedb20b88c8e38
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575165B2

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