Potassium Permanganate → HCID 67027109, Verbindung

HRID 2037318Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2037318
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1.[O-:11][Mn](=O)(=O)=O.[K+:16]>CC(C)=O>[K+:16].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([O-:11])=[O:10])[CH:3]=1

Komponenten

4

Edukt 2

HCID 516875Potassium PermanganateHCID 67027007(4-Bromo-6-methylpyridin-2-yl)methanol

Produkt 1

HCID 67027109HCID 67027109, VerbindungAusbeute 116 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of (4-bromo-6-methyl-pyridin-2-yl)-methanol (1.31 g, 6.48 mmol) in acetone (150 mL), KMnO4 (2.61 g, 16.5 mmol) is added. The mixture is stirred at 40° C. for 2 h before it is filtered over a sintered glass funnel. The filtrate is evaporated to dryness, and the remaining solid is washed with water and dried under HV to give 4-bromo-6-methyl-pyridine-2-carboxylic acid potassium salt (1.91 g) as a white solid; LC-MS: tR=0.45 min, [M+1]+=217.89.

Aufarbeitung

  1. filtrationis filtered over a sintered glass funnel
  2. customThe filtrate is evaporated to dryness
  3. washthe remaining solid is washed with water
  4. customdried under HV

Quellen und Nachweise

ORD-Eintrag
ord-e27fd69ef6824c73a10558590fe32f5b
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575200B2

Notizen zur Reaktion

Wird geladen…