Isopropylamine → HCID 57869849, Verbindung

HRID 2038621Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2038621
CO[C:3](=[O:13])[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH:14]([NH2:17])([CH3:16])[CH3:15]>CO>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:13])[NH:17][CH:14]([CH3:16])[CH3:15])[CH3:9])[CH3:12]

Komponenten

4

Edukt 2

HCID 6363Isopropylamine2×HCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

Produkt 1

HCID 57869849HCID 57869849, VerbindungAusbeute 13 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

To a known compound, 3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) were added methanol (3 ml) and isopropylamine (1.4 ml), and the mixture was stirred at 55° C. for 14 hours. Additional isopropylamine (1.0 ml) was added, and the mixture was stirred for 3 hours using a focused microwave synthesis system (Discover™, CEM) at 100 W. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-isopropylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (46 mg, 13% yield).

Aufarbeitung

  1. stirringthe mixture was stirred for 3 hours
  2. customa focused microwave synthesis system (Discover™, CEM) at 100 W
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-d6453c5c0cb142549faf539b92231cac
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575391B2

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