Hydrochloric Acid → (R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt

HRID 2038751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2038751
[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@H:8]([NH:10]S(C(C)(C)C)=O)[CH3:9])=[CH:4][CH:3]=1.[ClH:17].O1CCOCC1.CCOCC>CO>[ClH:17].[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 312751,4-DioxaneHCID 889592202-methyl-propane-2-sulfinic acid[(R)-1-(6-bromo-pyridin-3-yl)-ethyl]-amide

Produkt 1

HCID 53487712(R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl saltAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methyl-propane-2-sulfinic acid[(R)-1-(6-bromo-pyridin-3-yl)-ethyl]-amide (650 mg, 2.13 mmol) in MeOH (5 mL) was added 4.0M HCl in dioxane (5.32 mL, 21.30 mmol). The clear reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture became cloudy during this time. Ether (20 mL) was added, and the mixture was stirred for 10 min and then filtered, washed with ether (20 mL) to afford (R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt (500 mg, 87%) as a white solid.

Aufarbeitung

  1. stirringthe mixture was stirred for 10 min
  2. filtrationfiltered
  3. washwashed with ether (20 mL)

Quellen und Nachweise

ORD-Eintrag
ord-65baaa4f989049aaa2c3e6e1cb9a0a31
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575360B2

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