HCID 66922365, Verbindung → 1-Phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

HRID 2039831Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2039831
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]1=[O:17]>C(O)C.[Pd]>[C:11]1([N:4]2[C:5]3=[N:6][CH:7]=[CH:8][CH:9]=[C:10]3[CH2:2][C:3]2=[O:17])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 66922365HCID 66922365, Verbindung

Produkt 1

HCID 149872061-Phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-oneAusbeute 137,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The compound of step 2 (1.40 g, 3.80 mmol) was dissolved in ethanol (160 ml), and palladium on activated carbon (700 mg, 658 μmol, 10%) was added. The reaction mixture was hydrogenated (1 bar H2) at room temperature overnight. The mixture was filtered over celite, and the filtrate was evaporated under reduced pressure. Column chromatography of the residue on silica gel (EA (50%)/HEP) gave 1.10 g of the title compound.

Aufarbeitung

  1. customat room temperature
  2. customovernight
  3. filtrationThe mixture was filtered over celite
  4. customthe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3d21900645694cf0bab83775b169a4c2
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08580813B2

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