Hydrochloric Acid → HCID 67028844, Verbindung

HRID 2040014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2040014
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C@@H:11]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:12]([O:14]C)=[O:13])=[CH:6][CH:5]=1)[CH:2]=[CH2:3].[OH-].[Li+].Cl>O1CCOCC1.O>[CH2:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C@@H:11]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:12]([OH:14])=[O:13])=[CH:8][CH:9]=1)[CH:2]=[CH2:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67028712HCID 67028712, Verbindung

Produkt 1

HCID 67028844HCID 67028844, VerbindungAusbeute 97,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 218864351,4-Dioxane--water (1/1)Lösungsmittel

Versuchsvorschrift

A solution of 2.03 g (6.36 mmol) of methyl (R)-3-(4-allylphenyl)-2-tert-butoxycarbonylaminopropionate (prepared as in Synlett, 2005, 12, 1877-1880) in 20 ml of dioxane/water (1:1, v/v) and 0.30 g (12.71 mmol) of lithium hydroxide was stirred at RT for 2 h and then neutralized with 1N hydrochloric acid. The reaction mixture was extracted with ethyl acetate, and the organic phase was dried over Na2SO4, filtered and concentrated. 1.90 g of the title compound were obtained.

Aufarbeitung

  1. extractionThe reaction mixture was extracted with ethyl acetate
  2. dry with materialthe organic phase was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a19bc803592842a18063bf137794bee2
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08580777B2

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