Sodium Hydroxide → 922516-30-1

HRID 2043755Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2043755
[CH2:1]([C:3]1[N:7]([CH2:8][C:9]([O:11]CC)=[O:10])[N:6]=[C:5]([C:14]([F:17])([F:16])[F:15])[CH:4]=1)[CH3:2].[OH-].[Na+]>O1CCCC1.O>[CH2:1]([C:3]1[N:7]([CH2:8][C:9]([OH:11])=[O:10])[N:6]=[C:5]([C:14]([F:17])([F:16])[F:15])[CH:4]=1)[CH3:2]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 67464244ethyl 5-ethyl-3-(trifluoromethyl)-1H-pyrazole-1-acetate2×

Produkt 1

HCID 67464323922516-30-1Ausbeute 41,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ethyl 5-ethyl-3-(trifluoromethyl)-1H-pyrazole-1-acetate (1.34 g, 7.5 mmol) (i.e. the product of Example 16, Step B) in tetrahydrofuran (5 mL) was treated with sodium hydroxide (0.5 g) in water (3.5 mL). The reaction mixture was then stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and washed with diethyl ether. The resulting aqueous layer was acidified with concentrated hydrochloric acid to give a white precipitate. The precipitate was filtered and dried in air to give 690 mg of the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washwashed with diethyl ether
  3. customto give a white precipitate
  4. filtrationThe precipitate was filtered
  5. customdried in air

Quellen und Nachweise

ORD-Eintrag
ord-66ab70ac8810414a90e0aa00e94a5bba
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586611B2

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