Hydrochloric Acid → 922516-38-9

HRID 2043762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2043762
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][N:7]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[N:6]=1)=[O:4].[ClH:23]>C(OCC)C>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([N:7]2[CH:8]=[CH:9][C:5]([C:3]([O:2][CH3:1])=[O:4])=[N:6]2)[CH2:11][CH2:12]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 674641231,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate2×

Produkt 1

HCID 67461532922516-38-9

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of 1,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate (300 mg, 0.97 mmol) (i.e. the product of Example 18, Step B) in 5 mL of diethyl ether was added a 2 M solution of hydrogen chloride in ether (4.85 mL, 9.7 mmol), and the reaction mixture was stirred for 5 h at room temperature. The reaction mixture was evaporated in vacuo, the resulting residue was dissolved in methanol and concentrated in vacuo. The residue was dried in high vacuum to give 200 mg of the title compound as a white solid.

Aufarbeitung

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe resulting residue was dissolved in methanol
  3. concentrationconcentrated in vacuo
  4. customThe residue was dried in high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-38ab3ed50a94420386ba56960e957749
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586611B2

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