Reaktionsgleichung
C([O:3][C:4](=[O:32])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][C:29](=[O:31])[CH3:30])[CH:23]=2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:14])=[N:9][CH:8]=1)C.C1(CN(C2C=CC(F)=C(F)C=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.NC1C=C(NC(=O)C)C=CC=1.C(=O)CCCCC.C(OC(=O)CSC1SC(N)=NC=1)C>>[C:29]([NH:28][C:24]1[CH:23]=[C:22]([N:15]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:32])=[O:3])=[CH:8][N:9]=2)[CH:27]=[CH:26][CH:25]=1)(=[O:31])[CH3:30]Komponenten
6
Edukt 5
Produkt 1
Versuchsvorschrift
The title compound was prepared via {2-[3-(3-acetylamino-phenyl)-3-hexyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using N-(3-aminophenyl)-acetamide, hexanal and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.
Quellen und Nachweise
- ORD-Eintrag
- ord-edf1d1d3f4944202aa2f35a753853063
- Quelldatensatz
- uspto-grants-2013_11
- Patentnummer
- US08586614B2
Verknüpfte Notizen
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