Hydrochloric Acid → HCID 2959448, Verbindung

HRID 2045799Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2045799
[C:1]([CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:2].[ClH:16]>C(O)C.[Pd]>[ClH:16].[NH2:2][CH2:1][CH:3]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 12414061Ethyl 3-cyano-3-phenylpropanoate

Produkt 1

HCID 2959448HCID 2959448, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of ethyl 3-cyano-3-phenylpropanoate 2 (9.27 g, 45.6 mmol) in ethanol (70 mL) was added concentrated hydrochloric acid (2.4 mL) followed by 10% palladium on carbon (1.0 g) and the reaction hydrogenated at 80 psi for 18 h. The mixture was filtered through celite and concentrated in vacuo. The residue was triturated in ether and filtered to give 2 (4.97 g in 2 crops, 45%) as a white solid.

Aufarbeitung

  1. customthe reaction hydrogenated at 80 psi for 18 h
  2. filtrationThe mixture was filtered through celite and
  3. concentrationconcentrated in vacuo
  4. customThe residue was triturated in ether
  5. filtrationfiltered
  6. customto give 2 (4.97 g in 2 crops, 45%) as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-a1262f8e117d4da398c21aec6611a8b4
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592395B2

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