Methyl iodide → HCID 178503516, Verbindung

HRID 2046980Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2046980
[OH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12.[OH-].[Na+].[CH3:15]I>O>[OH:1][C:2]1[N:7]=[C:6]([S:8][CH3:15])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178434482HCID 178434482, Verbindung

Produkt 1

HCID 178503516HCID 178503516, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

4-hydroxy-6-mercapto-3-methylpyrazolo[3,4-d]pyrimidine (14 g) was dissolved in a solution of 10 g. of sodium hydroxide in 300 ml. of water. The solution was cooled to 5° C. and shaken with 12 g. of methyl iodide. After 15-20 minutes, the solution was charcoaled, filtered and acidified with acetic acid to yield 12 g. of crude product. Recrystallization in acidic acid gave the product. MS (ES+): 197.0 (M+1)+.

Aufarbeitung

  1. filtrationfiltered
  2. customto yield 12 g
  3. customRecrystallization in acidic acid
  4. customgave the product

Quellen und Nachweise

ORD-Eintrag
ord-29d24e21fbdc4f7494602f0b878ab211
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592432B2

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