Morpholine → 2-Methyl-6-(morpholin-4-yl)isonicotinic acid

HRID 2047278Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2047278
[CH2:1]([N:3]([CH2:14][CH3:15])[C:4]1[CH:5]=[C:6]([CH:10]=[C:11]([CH3:13])[N:12]=1)[C:7]([OH:9])=[O:8])[CH3:2].ClC1C=C(C=C(Cl)N=1)C(O)=[O:21].N1CCOCC1>>[CH3:13][C:11]1[CH:10]=[C:6]([CH:5]=[C:4]([N:3]2[CH2:1][CH2:2][O:21][CH2:15][CH2:14]2)[N:12]=1)[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 3

HCID 8083MorpholineHCID 948302,6-Dichloroisonicotinic acidHCID 584180552-(Diethylamino)-6-methylisonicotinic acid

Produkt 1

HCID 685781262-Methyl-6-(morpholin-4-yl)isonicotinic acid

Versuchsvorschrift

The title compound is prepared in analogy to 2-diethylamino-6-methyl-isonicotinic acid starting from 2,6-dichloro-isonicotinic acid and morpholine; LC-MS: tR=0.47 min, [M+1]+=223.08.

Quellen und Nachweise

ORD-Eintrag
ord-3b5a52dacf974329ad217890c408382a
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592460B2

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