Sodium Hydroxide → HCID 56591700, Verbindung

HRID 2047705

Reaktionsgleichung

Reaktionsgleichung von HRID 2047705
C[O:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[N:11]([CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[CH:10]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[C:22]([Cl:27])[CH:21]=3)[CH2:9][C:8]([CH2:29][CH3:30])([CH3:28])[C:7]=2[N:6]=1)=[O:4].[OH-].[Na+]>O1CCCC1.CO.O>[Cl:27][C:22]1[CH:21]=[C:20]([CH:10]2[CH2:9][C:8]([CH2:29][CH3:30])([CH3:28])[C:7]3[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:14]=[CH:13][C:12]=3[N:11]2[CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19])[CH:25]=[CH:24][C:23]=1[F:26]

Komponenten

6

Edukt 2

HCID 14798Sodium HydroxideHCID 665877056-(3-Chloro-4-fluoro-phenyl)-8-ethyl-8-methyl-5-(3-methyl-butyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carboxylic acid methyl ester

Produkt 1

HCID 56591700HCID 56591700, VerbindungAusbeute 35,8 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 6-(3-chloro-4-fluoro-phenyl)-8-ethyl-8-methyl-5-(3-methyl-butyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carboxylic acid methyl ester (100 mg, 0.2 mmol) in tetrahydrofuran (2 mL) and methanol (2 mL) was added 3 N sodium hydroxide (1 mL). The reaction mixture was stirred at room temperature for 16 hours, and then diluted with water (10 mL), extracted with diethyl ether (20 mL). The organic layer was discarded. The aqueous layer was acidified with concentrated hydrochloric acid to pH 4 and extracted with ethyl acetate (40 mL×3), and the combined organics were dried over anhydrous Na2SO4. The solvent was removed in vacuo and purified by preparative HPLC to afford 6-(3-chloro-4-fluoro-phenyl)-8-ethyl-8-methyl-5-(3-methyl-butyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carboxylic acid (30 mg, 31.3%) as a yellow oil. MS (ESI+) [(M+H)+] 419.1.

Aufarbeitung

  1. extractionextracted with diethyl ether (20 mL)
  2. extractionextracted with ethyl acetate (40 mL×3)
  3. dry with materialthe combined organics were dried over anhydrous Na2SO4
  4. customThe solvent was removed in vacuo
  5. custompurified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-e751588415974bbaaa8386904d2f9251
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592594B2

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