Ethyl Acetoacetate → (S)-ethyl 4-amino-5-(2-aminopropoxy)-2-methylquinoline-3-carboxylate
Reaktionsgleichung
[NH2:1][C:2]1[C:3]([C:23]#[N:24])=[C:4]([CH:20]=[CH:21][CH:22]=1)[O:5][CH2:6][C@@H:7]([NH:9]C(=O)OCC1C=CC=CC=1)[CH3:8].O=[C:26]([CH3:33])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[NH2:24][C:23]1[C:3]2[C:2](=[CH:22][CH:21]=[CH:20][C:4]=2[O:5][CH2:6][C@@H:7]([NH2:9])[CH3:8])[N:1]=[C:26]([CH3:33])[C:27]=1[C:28]([O:30][CH2:31][CH3:32])=[O:29]Komponenten
3
Versuchsvorschrift
Prepared as in Example 2a from (S)-benzyl (1-(3-amino-2-cyanophenoxy)propan-2-yl)-carbamate (Example 26c) and ethyl 3-oxobutanoate as brown solid. MS 304 (MH+).
Quellen und Nachweise
- ORD-Eintrag
- ord-d51b7b9157354706907504e325f252a0
- Quelldatensatz
- uspto-grants-2013_11
- Patentnummer