Ethanone, 2-chloro-1,2-diphenyl- → Thiazole, triphenyl-

HRID 2049272

Reaktionsgleichung

Reaktionsgleichung von HRID 2049272
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]1([C:16]([CH:18](Cl)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)(C)C>[C:10]1([C:16]2[S:8][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:9][C:18]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 95343Ethanone, 2-chloro-1,2-diphenyl-HCID 683563Thiobenzamide

Produkt 1

HCID 1712256Thiazole, triphenyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Thiobenzamide (13.7 g, 0.10 mole) and desyl chloride (23.1 g, 0.10 mole) are heated under reflux in isopropyl alcohol (100 ml) for three hours. When the reaction mixture is cooled, the white solid precipitate formed is filtered off, washed twice with isopropyl alcohol, and dried. The yield of triphenylthiazole, m.p. 84°-85.5° C., is 21.5 g or 69%.

Aufarbeitung

  1. temperatureWhen the reaction mixture is cooled
  2. customthe white solid precipitate formed
  3. filtrationis filtered off
  4. washwashed twice with isopropyl alcohol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3912ad2349f94687be5fa180fdf6869a
Quelldatensatz
uspto-grants-1980_04
Patentnummer
US04197306

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