Hydrochloric Acid → 6-(Hydroxymethyl)pyridin-3-ol hydrochloride

HRID 2049284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2049284
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]C(=O)C)=[CH:8][N:7]=1)(=O)C.[ClH:16]>CC(CC)=O>[ClH:16].[OH:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][OH:4])=[N:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 2715886-(Acetoxymethyl)pyridin-3-yl acetate

Produkt 1

HCID 187584236-(Hydroxymethyl)pyridin-3-ol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

220.0 g of the above ester is added to 2,200 ml of 6 N-hydrochloric acid and the resulting solution is refluxed for 18 hours. Then, the solution is evaporated to leave an oily viscous residue. This residue is digested with ethyl methyl ketone to yield 5-hydroxy-2-pyridinemethanol hydrochloride melting at 122°-123°. (The corresponding free base is prepared by adding a saturated solution of potassium carbonate to the hydrochloride, extracting the resulting suspension with chloroform, drying the chloroform extract over sodium sulfate, filtering and evaporating the filtrate to yield the free base.)

Aufarbeitung

  1. temperaturethe resulting solution is refluxed for 18 hours
  2. customThen, the solution is evaporated
  3. customto leave an oily viscous residue

Quellen und Nachweise

ORD-Eintrag
ord-fbd1595597484ba0a425ce752129329c
Quelldatensatz
uspto-grants-1980_04
Patentnummer
US04197302

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