Potassium Iodide → N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine

HRID 2049366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2049366
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+].I[CH2:25][CH2:26][CH3:27]>O.C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:25][CH2:26][CH3:27])[CH2:12][CH2:11]1

Komponenten

7

Edukt 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 336431-IodopropaneHCID 23339004N-(2,6-Dimethylphenyl)piperidin-4-amine

Produkt 1

HCID 23339025N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 241BenzeneLösungsmittel2×HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a warm (about 40° C.) and stirred mixture of 5 parts of N-(2,6-dimethylphenyl)-4-piperidinamine, 5 parts of sodium carbonate, a few crystals of potassium iodide in 120 parts of benzene is added dropwise a solution of 5.1 parts of 1-iodopropane in 80 parts of benzene. After the addition is complete, stirring is continued for 40 hours at reflux temperature. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried and evaporated in vacuo. The oily residue is distilled, yielding 10.2 parts of N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine; bp. 135° C. at 0.2 mm. pressure.

Aufarbeitung

  1. additionAfter the addition
  2. stirringstirring
  3. temperatureat reflux temperature
  4. temperatureThe reaction mixture is cooled
  5. customThe organic layer is separated
  6. customdried
  7. customevaporated in vacuo
  8. distillationThe oily residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-84bd7321f76a45bca15055962470d6df
Quelldatensatz
uspto-grants-1980_04
Patentnummer
US04197304

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