Sodium Cyanide → HCID 20344097, Verbindung

HRID 2049631Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2049631
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.[C-:17]#[N:18].[Na+]>C(O)C.O>[F:16][C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=1)[O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][C:17]#[N:18]

Komponenten

5

Edukt 2

HCID 8929Sodium CyanideHCID 20344102HCID 20344102, Verbindung

Produkt 1

HCID 20344097HCID 20344097, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

1-(Chloromethyl)-2-(3-fluorophenoxy)benzene (26.5 g.) was dissolved in 300 ml of ethanol; a solution of sodium cyanide (7.8 g.) in 15 ml of water was added, and the resulting mixture was heated to reflux overnight. The ethanol was evaporated, the residue taken up in water, extracted with ether and the combined ether extracts were dried and concentrated to give the title compound. ##STR13##

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureto reflux overnight
  3. customThe ethanol was evaporated
  4. extractionextracted with ether
  5. dry with materialthe combined ether extracts were dried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-80b7f065ce434db98481f731fca32278
Quelldatensatz
uspto-grants-1980_04
Patentnummer
US04198421

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