3-Aminopropyl(phenyl)phosphinic acid → 3-Aminopropyl(cyclohexyl)phosphinic acid

HRID 2050696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2050696
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:7])[OH:6].[H][H]>O.Cl>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)(=[O:6])[OH:7]

Komponenten

5

Edukt 2

HCID 101042063-Aminopropyl(phenyl)phosphinic acidHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 99207013-Aminopropyl(cyclohexyl)phosphinic acidAusbeute 5.311,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 1.5 g of 3-aminopropyl(phenyl)phosphinic acid in 10 ml of water and 7.9 ml of 1N hydrochloric acid is treated with hydrogen at 25° in the presence of 0.2 g of Nishimura-catalyst (Rh/PtO2). After 1.2 hours hydrogen up-take stops. The reaction mixture is filtered and the filtrate evaporated to dryness. The residue is recrystallized from methanol/propylenoxide to give 1.2 g of 3-aminopropyl(cyclohexyl)phosphinic acid x 0,4 mol hydrochloric acid as a white solid, m.p. 202-203°.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate evaporated to dryness
  3. customThe residue is recrystallized from methanol/propylenoxide

Quellen und Nachweise

ORD-Eintrag
ord-ae2f5ae6bc124127b1c71c06525ba10d
Quelldatensatz
uspto-grants-1991_05
Patentnummer
US05013863

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