Formaldehyde → Tetrahydro-N-methyl-N-(phosphonomethyl)-3-thiophenamine 1,1-dioxide

HRID 2051676

Reaktionsgleichung

Reaktionsgleichung von HRID 2051676
Cl.[CH3:2][NH:3][CH:4]1[CH2:8][CH2:7][S:6](=[O:10])(=[O:9])[CH2:5]1.[CH2:11]=O.[P:13]([OH:16])([OH:15])[OH:14].O>C(O)C>[CH3:2][N:3]([CH2:11][P:13]([OH:16])([OH:15])=[O:14])[CH:4]1[CH2:8][CH2:7][S:6](=[O:10])(=[O:9])[CH2:5]1

Komponenten

6

Edukt 4

HCID 712FormaldehydeHCID 962WaterHCID 107909Phosphorous acidHCID 27708173-(Methylamino)-1lambda6-thiolane-1,1-dione hydrochloride

Produkt 1

HCID 20509047Tetrahydro-N-methyl-N-(phosphonomethyl)-3-thiophenamine 1,1-dioxideAusbeute 86,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of N-methyltetrahydro-3-thiophenamine 1,1-dioxide hydrochloride (37.2 parts, 0.20 mole); 90 percent paraformaldehyde (6.8 parts, 0.22 mole); orthophosphorous acid (18.0 parts, 0.22 mole); and water (30 parts) was heated at its reflex temperature for 3 hours. After cooling, the solution was stirred into ethanol (150 ml.) and the sticky, white precipitate was triturated under more ethanol. After being dried in vacuo over P2O5 the product weighed 42.0 g. (86.3 percent yield). m.p. 222°-225° C.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe sticky, white precipitate was triturated under more ethanol
  3. dry with materialAfter being dried in vacuo over P2O5 the product

Quellen und Nachweise

ORD-Eintrag
ord-5da9cf5125984a4f8fe5fd7dcf6c9322
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04181806

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