Ethyl Bromide → 5-(Ethylamino)-2-methylphenol

HRID 2052526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2052526
[CH2:1](Br)[CH3:2].[NH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([OH:11])[CH:10]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C.O>[CH2:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:12])=[C:9]([OH:11])[CH:10]=1)[CH3:2]

Komponenten

6

Edukt 3

HCID 6332Ethyl BromideHCID 10340Sodium CarbonateHCID 178185-Amino-2-methylphenol

Produkt 1

HCID 158012485-(Ethylamino)-2-methylphenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

88.6 gm of ethyl bromide were added to a solution of 50 gm of 5-amino-2-methylphenol in 250 ml of ethanol; and the mixture was refluxed for four hours. After the solution had cooled, it was diluted with 1.2 liters of water and was made weakly alkaline with sodium carbonate. After repeated extraction with ether, the ether extracts were dried and concentrated. The residue was recrystallized from ethanol, and had a melting point of 128° C. to 129° C.

Aufarbeitung

  1. temperatureand the mixture was refluxed for four hours
  2. temperatureAfter the solution had cooled
  3. extractionextraction with ether
  4. dry with materialthe ether extracts were dried
  5. concentrationconcentrated
  6. customThe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f30ad37330bc41f895fe9d47caa7b121
Quelldatensatz
uspto-grants-1980_01
Patentnummer
USRE030199

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