Hydrochloric Acid → Methyl 3-(aminomethyl)benzoate

A 20% solution of piperidine in DMF (5 ml) was added to 3-[(9H-Fluoren-9-ylmethoxycarbonylamino)-methyl]-benzoic acid methyl ester (193 mg, 0.5 mmol) and the reaction was stirred at room temperature for 30 min. Water (10 ml) was added to the crude reaction mixture, followed by 1M HCl (10 ml). The aqueous layer was washed with EtOAc (3×10 ml) then basified to pH 9 with saturated NaHCO3. The basic layer was extracted with EtOAc (3×10 ml) and the aqueous layer was evaporated down to a small volume, then further extracted with EtOAc (5×10 ml). The combined organic layers were dried (MgSO4), filtered and the solvent evaporated in vacuo to give the title compound.

1. customreaction mixture
2. washThe aqueous layer was washed with EtOAc (3×10 ml)
3. extractionThe basic layer was extracted with EtOAc (3×10 ml)
4. customthe aqueous layer was evaporated down to a small volume
5. extractionfurther extracted with EtOAc (5×10 ml)
6. dry with materialThe combined organic layers were dried (MgSO4)
7. filtrationfiltered
8. customthe solvent evaporated in vacuo

ORD-Eintrag

ord-c11a812efa3e4b6eae09f469752b0d5c

Quelldatensatz

uspto-grants-2008_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07326732B2