2-Acetylamino-5-nitroquinoline → 2-Acetylamino-5-aminoquinoline

HRID 2054947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2054947
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N+:15]([O-])=O)[N:6]=1)(=[O:3])[CH3:2].[H][H]>C(OCC)(=O)C.CO.[Pd]>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 219488732-Acetylamino-5-nitroquinolineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 219488292-Acetylamino-5-aminoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 21584119Ethylacetate methanolLösungsmittel

Versuchsvorschrift

400 mg (1.7 mmol) of 2-acetylamino-5-nitroquinoline and 105 mg of 10% Pd—C are stirred in 20 ml of ethyl acetate-MeOH (3:1) for 4 hours in a hydrogen atmosphere at room temperature. The batch is filtered, concentrated by evaporation and purified by column chromatography on silica gel with hexane-ethyl acetate: 210 mg of product.

Aufarbeitung

  1. filtrationThe batch is filtered
  2. concentrationconcentrated by evaporation
  3. custompurified by column chromatography on silica gel with hexane-ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-259bdd85074b4beba755de77934ebd78
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07329753B2

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