Water → 4-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)pentanoic acid methyl ester

HRID 2055131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2055131
[H-].[Na+].C(OP([CH2:11][C:12]([O:14][CH3:15])=[O:13])(OCC)=O)C.[CH3:16][C:17]([N:21]1[CH:25]=[C:24]([C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)[N:23]=[CH:22]1)([CH3:20])[CH:18]=O.O>C1COCC1>[CH3:15][O:14][C:12](=[O:13])[CH2:11][CH2:18][C:17]([CH3:20])([N:21]1[CH:25]=[C:24]([C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)[N:23]=[CH:22]1)[CH3:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 24758Sodium hydrideHCID 66113Methyl diethylphosphonoacetateHCID 235114292-Methyl-2-(4-pyridin-3-yl-imidazol-1-yl)-propionaldehyde

Produkt 1

HCID 207376634-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)pentanoic acid methyl esterAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a solution of sodium hydride (1.2 eq) in THF was added slowly methyl diethylphosphonoacetate (1.2 eq) at 0° C. under dry conditions and the mixture was stirred at room temperature for 30 minutes. A solution of 2-methyl-2-(4-pyridin-3-yl-imidazol-1-yl)-propionaldehyde (1 eq), in THF was added dropwise at room temperature and the mixture was stirred for 1 hour at the same temperature. The mixture was poured into H2O and the whole was extracted with ethyl acetate. The organic layer was washed with NaCl (sat.), dried over sodium sulfate, filtered, and concentrated. To a solution of the residue in ethyl acetate, was added palladium, 10 wt. % on activated carbon and left stirring under 1 atm hydrogen overnight. After the catalyst was filtered off, the filtrate was purified by flash chromatography using a solvent gradient 97% DCM, 3% MeOH, and 0.1% TEA to yield 4-methyl-4-(4-pyridin-3-yl-imidazol-1-yl)pentanoic acid methyl ester (75%). MH+(274)

Aufarbeitung

  1. stirringthe mixture was stirred for 1 hour at the same temperature
  2. extractionthe whole was extracted with ethyl acetate
  3. washThe organic layer was washed with NaCl (sat.)
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. additionTo a solution of the residue in ethyl acetate, was added palladium, 10 wt. % on activated carbon
  8. waitleft
  9. stirringstirring under 1 atm hydrogen overnight
  10. filtrationAfter the catalyst was filtered off
  11. customthe filtrate was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2703104306094188a0eed0779556293a
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07332476B2

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