Methanesulfonyl chloride → 2-{(1S)-6-[(Diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethyl methanesulfonate

Reaktionsgleichung

[C:1]1([C:7](=[N:14][C:15]2[CH:16]=[CH:17][C:18]3[C@H:23]([CH2:24][CH2:25][OH:26])[O:22][CH2:21][CH2:20][C:19]=3[CH:27]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30].CS(OCC[C@H]1C2C=CC(C(N)=O)=CC=2CCO1)(=O)=O>>[CH3:28][S:29]([O:26][CH2:25][CH2:24][C@H:23]1[C:18]2[CH:17]=[CH:16][C:15]([N:14]=[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:27][C:19]=2[CH2:20][CH2:21][O:22]1)(=[O:31])=[O:30]

Komponenten

Edukt 3

HCID 31297Methanesulfonyl chloride

HCID 865960122-[(1S)-6-(aminocarbonyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate

HCID 865960172-{(1S)-6-[(diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethanol

Produkt 1

HCID 865960202-{(1S)-6-[(Diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethyl methanesulfonate

Versuchsvorschrift

2-{(1S)-6-[(Diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethanol was reacted with methanesulfonyl chloride, as described for the preparation of 2-[(1S)-6-(aminocarbonyl)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl methanesulfonate, to yield 2-{(1S)-6-[(diphenylmethylene)amino]-3,4-dihydro-1H-2-benzopyran-1-yl}ethyl methanesulfonate.