Morpholine → Moclobemide

HRID 2057461

Reaktionsgleichung

Reaktionsgleichung von HRID 2057461
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]2[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:10][CH2:9][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[O:7])=[CH:11][CH:12]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 2450271-(4-Chlorobenzoyl)aziridine

Produkt 1

HCID 4235Moclobemide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

55.4 G. of p-chlorobenzoylaziridine and 26.5 g. of morpholine are boiled in 250 ml. of toluene for 2 hours under reflux. The solution is then cooled to room temperature, whereupon crystals separate out. The solution which crystallizes is allowed to stand overnight in a refrigerator. Thereafter, the product is removed by filtration, washed with toluene and recrystallized from isopropanol, and 75.9 g. of p-chloro-N-(2-morpholinoethyl)-benzamide are obtained, which is identical to the product obtained in Example 1.

Aufarbeitung

  1. customseparate out
  2. customThe solution which crystallizes
  3. customThereafter, the product is removed by filtration
  4. washwashed with toluene
  5. customrecrystallized from isopropanol, and 75.9 g

Quellen und Nachweise

ORD-Eintrag
ord-6a997b4ee6b14561a49738f88756156d
Quelldatensatz
uspto-grants-1980_07
Patentnummer
US04210754

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