Acetic Anhydride → 7-(1-ethyl-2-methyl-3-indolyl)-7-(diphenylamino)furo[3,4-b]pyrazine-5(7H)-one

HRID 2057638

Reaktionsgleichung

Reaktionsgleichung von HRID 2057638
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([C:14]2[C:15]([C:20](O)=[O:21])=[N:16][CH:17]=[CH:18][N:19]=2)=[O:13])=[C:4]1[CH3:23])[CH3:2].[C:24]1([NH:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(OC(=O)C)(=O)C>>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2([N:30]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:14]3=[N:19][CH:18]=[CH:17][N:16]=[C:15]3[C:20](=[O:21])[O:13]2)=[C:4]1[CH3:23])[CH3:2]

Komponenten

4

Edukt 3

HCID 7918Acetic AnhydrideHCID 11487DiphenylamineHCID 20534320(1-Ethyl-2-methylindol-3-yl)-(2-carboxypyrazin-3-yl)ketone

Produkt 1

HCID 205342777-(1-ethyl-2-methyl-3-indolyl)-7-(diphenylamino)furo[3,4-b]pyrazine-5(7H)-one

Versuchsvorschrift

A mixture containing 4 g. of 3-[(1-ethyl-2-methyl-3-indolyl)carbonyl]-2-pyrazinecarboxylic acid, 1.7 g. of diphenylamine and 15 ml. of acetic anhydride was stirred 1 hour at room temperature and then 30 minutes with gentle warming. The product, 7-(1-ethyl-2-methyl-3-indolyl)-7-(diphenylamino)furo[3,4-b]pyrazine-5(7H)-one was isolated by column chromatography as a red solid, m.p. 98°-100° C. A toluene solution of this product contacted with acidic clay or phenolic resin developed an orange image.

Aufarbeitung

  1. additionA mixture containing 4 g
  2. custom30 minutes

Quellen und Nachweise

ORD-Eintrag
ord-19dbb90aed7948408e520c8505f4bb92
Quelldatensatz
uspto-grants-1980_07
Patentnummer
US04211872

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