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Benzenesulfonamide → 4-[13-(4-chlorophenyl)tridec-12-ynylamino]-N-(phenylsulfonyl)benzamide

HRID 2057670
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2057670
[C:1]1([S:7]([NH2:10])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]#[C:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][CH:35]=2)=[CH:16][CH:15]=1.S(Cl)(Cl)=O>C(COC)OC.C(Cl)Cl.CC(N(C)C)=O>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]#[C:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]2[CH:35]=[CH:36][C:37]([C:38]([NH:10][S:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:9])=[O:8])=[O:39])=[CH:41][CH:42]=2)=[CH:18][CH:19]=1
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Komponenten

8

Edukt 4

HCID 7370BenzenesulfonamideHCID 24386Thionyl ChlorideHCID 24758Sodium hydrideHCID 203309694-[13-(4-Chlorophenyl)-12-tridecynylamino]benzoic acid

Produkt 1

HCID 203312704-[13-(4-chlorophenyl)tridec-12-ynylamino]-N-(phenylsulfonyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 6344
Dichloromethane
Lösungsmittel
HCID 80711,2-DimethoxyethaneLösungsmittel
HCID 31374DimethylacetamideLösungsmittel2×

Versuchsvorschrift

A solution of 31.4 g. of benzenesulfonamide in 250 ml. of dry dimethylacetamide is added dropwise, with stirring and cooling, to a suspension of 5.5 g. of sodium hydride in 100 ml. of dry dimethylacetamide during 30 minutes at room temperature. Stirring is continued for a further 30 minutes. In the meantime, a mixture of 36.5 g. of 4-[13-(4-chlorophenyl)tridec-12-ynylamino]benzoic acid in 100 ml. of methylene chloride, 300 ml. of dimethoxyethane, and 40 ml. of thionyl chloride is refluxed for 1 hour and 15 minutes. The solution is evaporated and to the resulting oil residue is added, in one portion, the previously prepared mixture of sodium benzenesulfonamide in dimethylacetamide. The mixture is stirred for 30 minutes, without cooling, and then filtered. The filtrate is poured into 2 l. of water and 250 ml. of saturated sodium chloride solution. The product is collected by filtration and then dissolved in methylene chloride, the mixture is filtered through diatomaceous earth, and brine is added to break the emulsion. The layers are separated, the organic phase is dried and evaporated. The residue is crystallized from toluene to yield 4-[13-(4-chlorophenyl)tridec-12-ynylamino]-N-(phenylsulfonyl)benzamide.

Aufarbeitung

  1. temperaturecooling, to a suspension of 5.5 g
  2. stirringStirring
  3. additionIn the meantime, a mixture of 36.5 g
  4. customThe solution is evaporated and to the resulting oil residue
  5. additionis added, in one portion
  6. additionthe previously prepared mixture of sodium benzenesulfonamide in dimethylacetamide
  7. stirringThe mixture is stirred for 30 minutes
  8. temperaturewithout cooling
  9. filtrationfiltered
  10. additionThe filtrate is poured into 2 l
  11. filtrationThe product is collected by filtration
  12. dissolutiondissolved in methylene chloride
  13. filtrationthe mixture is filtered through diatomaceous earth, and brine
  14. additionis added
  15. customThe layers are separated
  16. customthe organic phase is dried
  17. customevaporated
  18. customThe residue is crystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-28966f082ad1490e8f2521413ef3e960
Quelldatensatz
uspto-grants-1980_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04211783

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