Plomestane → HCID 86738325, Verbindung

HRID 2059304Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059304
[CH2:1]([C@@:4]12[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16](=[O:22])[CH2:15][CH2:14]4)[CH2:11][CH2:10][C:9]1=[CH:8][C:7](=[O:23])[CH2:6][CH2:5]2)[C:2]#[CH:3]>O1CCOCC1.CCOCC>[CH2:1]([C@@:4]12[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16](=[O:22])[CH2:15][CH2:14]4)[CH2:11][CH2:10][C:9]1=[CH:8][C:7](=[O:23])[CH:6]=[CH:5]2)[C:2]#[CH:3]

Komponenten

4

Edukt 1

HCID 9904788Plomestane

Produkt 1

HCID 86738325HCID 86738325, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 150 mg of 10-(2-propynyl)-estr-4-ene-3,17-dione, and 300 mg of dichlorodicyanoquinone in 10 ml of dioxane is refluxed for 20 hours. The mixture is cooled and diluted with ether and then washed with aqueous sodium carbonate and dried. The solvent is evaporated and the residue is chromatographed on silica gel in ethyl acetate/hexane to give 10-(2-propynyl)-estra-1,4-diene-3,17-dione melting at about 200°-201° C. This compound has the following structural formula ##STR11##

Aufarbeitung

  1. temperatureis refluxed for 20 hours
  2. temperatureThe mixture is cooled
  3. washwashed with aqueous sodium carbonate
  4. customdried
  5. customThe solvent is evaporated
  6. customthe residue is chromatographed on silica gel in ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-4826164723a24b618e15a576aa0fbd0e
Quelldatensatz
uspto-grants-1982_03
Patentnummer
US04322416

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