(5-(4-(4-((3-Fluorobenzyl)oxy)-3-chloroanilino)-6-quinazolinyl)-2-furancarboxaldehyde → HCID 178502700, Verbindung

HRID 2059458Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059458
O=Cc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1.CON(C)C(=O)CC(=O)O>NCc1ccccc1.O=C(O)C(F)(F)F.CN(C)c1ccncc1.CN(C)C=O>CON(C)C(=O)/C=C/c1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1

Komponenten

6

Edukt 2

HCID 11181296(5-(4-(4-((3-Fluorobenzyl)oxy)-3-chloroanilino)-6-quinazolinyl)-2-furancarboxaldehydeHCID 11263568HCID 11263568, Verbindung

Produkt 1

HCID 178502700HCID 178502700, VerbindungAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 142844-(Dimethylamino)pyridineReagenzHCID 12484433Benzenemethanamine, trifluoroacetateKatalysatorHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Aufarbeitung

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic-Phase beibehalten
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Quellen und Nachweise

ORD-Eintrag
ord-01e04eeb2be04ecb80d130e0c31917fe
Quelldatensatz
Transfer learning optimization of 26 decarboxylative olefination reactions

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