Sodium Hydroxide → Bupivacaine (USAN:INN:BAN)

HRID 2059964

Reaktionsgleichung

Reaktionsgleichung von HRID 2059964
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 64737Bupivacaine Hydrochloride

Produkt 1

HCID 2474Bupivacaine (USAN:INN:BAN)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (1 N solution) was added to the solution and the pH of the final mixtures was adjusted to 10 to precipitate the BP bate. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at approximately 40° C. in vacuum for 24 h.

Aufarbeitung

  1. customto precipitate the BP bate
  2. filtrationThe precipitated product was filtered
  3. washfurther washed with DI water for at least three times
  4. customThe precipitated product was dried at approximately 40° C. in vacuum for 24 h.

Quellen und Nachweise

ORD-Eintrag
ord-bbe0ae0487d0453db13663838e0d921d
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278330B2

Verknüpfte Notizen

Wird geladen…