Acetic Anhydride → 1-Acetyl-5-fluoro-1,3-dihydro-indol-2-one

HRID 2059975Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059975
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[CH2:5][C:6]1=[O:11])(=[O:14])[CH3:13]

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 37310125-fluoro-1,3-dihydro-2H-indol-2-one

Produkt 1

HCID 583867501-Acetyl-5-fluoro-1,3-dihydro-indol-2-one

Versuchsvorschrift

At 170° C. 3.0 g (20 mmol) 5-fluoroindolinone were stirred in 10 mL (98 mmol) acetic anhydride for 3 h. After cooling to RT the mixture was poured onto 200 mL ice water, the precipitated substance was suction filtered and washed with 100 mL water. The solid was recrystallised from water and ethanol. The precipitated product was suction filtered, washed with water and dried i. vac.

Aufarbeitung

  1. customAt 170° C
  2. filtrationfiltered
  3. washwashed with 100 mL water
  4. customThe solid was recrystallised from water and ethanol
  5. filtrationfiltered
  6. washwashed with water
  7. customdried i

Quellen und Nachweise

ORD-Eintrag
ord-0d84cf368835448cad78b1bb742f3fce
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278336B2

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