Pyridinium chloride → HCID 42613602, Verbindung

HRID 2059986

Reaktionsgleichung

Reaktionsgleichung von HRID 2059986
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([C:13]1[N:18]=[C:17]([O:19]C)[CH:16]=[C:15]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[C:35]5[C:30](=[N:31][CH:32]=[CH:33][CH:34]=5)[NH:29][C:28]4=[O:36])[CH2:23][CH2:22]3)[CH:14]=1)=[O:12])[CH2:6][CH2:5]2.Cl.N1C=CC=CC=1>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([C:13]1[NH:18][C:17](=[O:19])[CH:16]=[C:15]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[C:35]5[C:30](=[N:31][CH:32]=[CH:33][CH:34]=5)[NH:29][C:28]4=[O:36])[CH2:23][CH2:22]3)[CH:14]=1)=[O:12])[CH2:6][CH2:5]2

Komponenten

4

Edukt 2

HCID 10176127Pyridinium chlorideHCID 583865521-[6'-(5-Fluoro-2,3-dihydro-indole-1-carbonyl)-2'-methoxy-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Produkt 1

HCID 42613602HCID 42613602, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A well stirred mixture of 40 mg (0.082 mmol) 1-[6′-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-2′-methoxy-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl]-1,3-dihydro-imidazo-[4,5-b]pyridin-2-one and 0.020 g (1.7 mmol) pyridine hydrochloride was kept in a melt for 2 min using a hot air blower. After the reaction had cooled the mixture was dissolved in DMF and purified by preparative HPLC. The product-containing fractions were combined and lyophilised.

Aufarbeitung

  1. temperatureAfter the reaction had cooled the mixture
  2. custompurified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-397ecc7a60864ca6a726ef71959024f5
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278336B2

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