Sodium Hydroxide → HCID 68802039, Verbindung

HRID 2060071Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2060071
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=2)[C:7]1=[O:20])[CH3:4].[OH-].[Na+]>O>[CH3:4][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:17])[F:18])[CH:12]=2)[C:7]1=[O:20])[CH3:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 694507812-Dimethylaminomethyl-5-trifluoromethoxy-indan-1-one hydrochloride

Produkt 1

HCID 68802039HCID 68802039, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

14 g of the product from step 3 were dissolved in water; the solution was adjusted to pH 12 with 32% sodium hydroxide solution, while cooling with ice, and extracted three times with dichloromethane, and the combined organic phases were dried over magnesium sulfate, filtered and concentrated in vacuo.

Aufarbeitung

  1. temperaturewhile cooling with ice
  2. extractionextracted three times with dichloromethane
  3. dry with materialthe combined organic phases were dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-778622f470074d93814ea356c2bf25bd
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278338B2

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