Hydrazine hydrate (1:1) → 2371-31-5

HRID 2061406

Reaktionsgleichung

Reaktionsgleichung von HRID 2061406
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12]CC)=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([NH:16][NH2:17])=[O:12])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester

Produkt 1

HCID 3026472371-31-5Ausbeute 59 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 2-(4-chlorophenylamino)acetate (A) (25.6 g, 120 mmol) and hydrazine monohydrate (7.0 mL, 144 mmol) were heated to reflux in ethanol (120 mL) for 22 hours. After concentration in vacuo, the solid obtained was recrystallised from ethanol to yield the title compound (14.0 g, 59%) as a pale brown powder. 1H NMR (400 MHz, CDCl3) δ 3.85 (2H, d), 4.18 (2H, br), 6.53 (2H, d), 7.16 (2H, d), 7.60 (1H, br).

Aufarbeitung

  1. concentrationAfter concentration in vacuo
  2. customthe solid obtained
  3. customwas recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4de39e719876495c897ec661c521281c
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08283351B2

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